Bioconjugation & Antibody-Drug Conjugates
TCRS has ample experience in providing antibody-drug conjugate related services to its clients. Currently, TCRS is engaged in supporting several biotech and pharmaceutical companies in the development of their ADC programs. TCRS has a variety of highly potent warheads/payloads in stock for advancing its clients' ADC projects. A selection of cleavable and non-cleavable linkers and spacer molecules is also available.
TCRS has more than 20 different payloads in its toolbox for preparing ADCs or PDCs which include:
- Dolastatin-10 and Auristatin analogs
- Duocarmycin analogs
- Maytansine analogs
- PBD dimer analogs
- additional payloads
Other Bioconjugation Services include:
- Design and synthesis of potent cytotoxic compounds and payloads with linkers
- Customized design and synthesis of linkers
- Preparation and purification of bioconjugates from milligram- to gram-scale
- Modification of carbohydrates, polysaccharides, and glycoconjugates
- Preparation of fluorescent probes
TCRS conducts all work with highly toxic/cytotoxic compounds and payloads in its specially designed containment laboratory which is accessible only to authorized and trained TCRS chemists. This laboratory has an independent air-handling (HVAC) system and is equipped with certified chemical fume hoods, HEPA-filtered ventilation and enclosed, HEPA-ventilated weighing stations. Compounds of high toxicity are handled in a glove box with a closed-loop containment (CLC) system that operates under negative pressure.
TCRS offers an "Express Conjugation Service" where clients may choose from a toolbox of numerous payload-linker combinations for the expeditious production of conjugates.
For further information, click here.